Introduction of water soluble antimicrobial silver acrylate copolymer(poly(sodium acrylate-co-silver acrylate))

Antimicrobial polymer

There is an increasing interest in selective antimicrobial polymers whose potency against bacteria and less toxicity towards mammalian cells distinguishes them from most small molecule and polymeric biocides that are broadly poisonous. In addition, the use of polymeric antimicrobial agents have the advantages that they are nonvolatile, chemically stable, and find it difficult to permeate through the skin of man or animal and minimize the environmental problems accompanying the residual toxicity of the agents in addition to prolonging their lifetime.

Antimicrobial silver(Quoted from Microbe wiki)

The antimicrobial properties of silver have been known to cultures all around the world for many centuries. The

Phoenicians stored water and other liquids in silver coated bottles to discourage contamination by microbes (Wikipedia: Silver). Silver dollars used to be put into milk bottles to keep milk fresh, and water tanks of ships and airplanes that are

"silvered" are able to render water potable for months ( In 1884 it became a common practice to administer drops of aqueous silver nitrate to newborn's eyes to prevent the transmission of Neisseria gonorrhoeae from infected mothers to children during childbirth (Silvestry-Rodriguez et al., 2007). In 1893, the antibacterial effectiveness of

various metals were noted and this property was named the oligodynamic effect. It was later found that out of all the metals with antimicrobial properties, silver has the most effective antibacterial action and the least toxicity to animal cells

(Guggenbichler et al., 1999). Silver became commonly used in medical treatments, such as those of wounded soldiers in World War I, to deter microbial growth ( Once antibiotics were discovered, the use of silver as a bactericidal agent decreased. However, with the discovery of antibiotics came the emergence of antibiotic-resistant strains such as CA-MRSA and HA-MRSA, the flesh-eating bacteria. Due to increasing antibiotic resistance, there has recently been a renewed interest in using silver as an antibacterial agent.

water soluble antimicrobial silver acrylate copolymer(poly(sodium acrylate-co-silver acrylate))

Silver acrylate copolymer is the world’s first antimicrobial polymer that is silver complexed and water soluble. Silver acrylate copolymer is random copolymer of sodium acrylate and silver acrylate.

The molecular weight of silver acrylate copolymer is over 5,000,000.

The weight ratio of Ag in the polymer chain is 40% and can be adjusted in the synthesis process.

The properties of water soluble silver acrylate copolymer

Highly effective antimicrobial properties with broad spectrum

no antimicrobial resistant issue

Non-volatile and chemically stable

Safe and non irritative

 Possible applications for silver acrylate copolymer

Medical applications : wound dressing, antibacterial hydrogel, antifungal cream, disinfectants

Hygiene products : dental hygiene products , women’s hygiene products, deodorant, personal hygiene products

Preservatives : cosmetic products, personal hygiene products, food products

Other antimicrobial applications

The antimicrobial test of Acrylsilver solution by SGS

Test solution : Acrylsilver aqueous solution(silver content is about 100ppm))

Testing method : U.S.Pharmacopeia 35 NF 30 Microbiological Tests(51)Antimicrobial Effectiveness Testing

Microorganism : Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginos, Methicillin-resistant Staphylococcus aureus (MRSA)

Volume ratio : Acrylsiver aqueous solution(100ppm of Ag) : inoculum = 20ML:0.2ML

Contact time : 1 minut

Antibacterial resistant ratio = 99.999%

SGS test report 1
SGS test report 2